Fasciitis associated with generalized morphea.

Figure 1. Photograph of the legs. A large, thickened, firm, hyper/hypopigmented plaque is evident on the left leg. Figure 2. Biopsies of affected skin (A) and contiguous tibialis anterior muscle and fascia from the left leg (B–D). (A) The der-mal collagen is thickened, packed, and hyalinized. The subcutaneous fat is extensively replaced by collagen, and perivascular inflammatory infiltrates are present (HE stain, ×50). (B) Fibrosis and inflammatory infiltration in the epimysium, the adjacent endomysium, and perivascular sites (HE stain, ×200). (C) Mild variation of fiber size and increased perimysial connective tissue with perimysial and perivascular infiltration (HE stain, ×100). (D) Mononuclear cell infiltration in the superficial layer of the fascia (HE stain, ×200).